Beauty Industry Bulletins

Extract of a hop variety relieves symptoms in the mouse arthritis model

In a study recently published in the International Journal of Molecular Medicine, researchers from several South Korean institutes and universities examined the effects of a Humulus japonicus extract on test mice who had developed symptoms of rheumatoid arthritis.

Long-standing component of Asian herbal medicines

Humulus japonicus or Japanese hops (also known as wild hops) is a member of the hemp family native to East Asia. It was imported into the United States as an ornamental plant and is now endemic to eastern North America, where it is considered an invasive species.

Japanese hops have long been a raw material used in traditional Asian herbal medicine. It is said to have antioxidant, antimicrobial and anti-inflammatory effects.

In at least one case, the botanical was too examined for its anti-obesity effects. In another Korean study published in 2018, researchers claimed that an aqueous extract of the herb improved hyperlipidemia and markers of non-alcoholic fatty liver disease in a test group of obese mice.

In the most recent study, researchers used an ethanolic extract of the plant made by the Korea Bioactive Natural Material Bank. The dried above-ground parts of a verified batch of material were soaked in 70% ethanol for two days to obtain the test material.

Arthritis induced by collagen injections

The test mice were induced with symptoms mimicking rheumatoid arthritis by multiple injections of type II bovine collagen. The degree of symptoms was measured by paw swelling.

The mice were immunized with the collagen on days 1 and 21. Oral treatment with the test extract at a dose of 300 mg / kg began three days before the second injection and continued until day 35, the last day of the study, when the mice were euthanized. The control group of mice was fed a replacement vehicle.

In addition to measuring the paw swelling in the living mice, the hind paws of the animals were collected at the end of the experiment. The paws were cut into sections and examined for signs of joint soft tissue and bone damage.

The researchers found that the mice treated with HJ extract had less soft tissue damage in their hind paws and less swelling in both pairs of paws. In addition, these mice showed lower levels of proinflammatory mediators than the control group mice.

“[T]To the best of our knowledge, this is the first study to suggest that during the development of RA in CIA mice, HJ has protective effects on the inflammation and destruction of cartilage and bone by inhibiting the secretion of proinflammatory mediators and the formation of osteoclasts “Concluded the researchers.

Source:International Journal of Molecular Medicine
DOI: 10.3892 / iymm.2019.4417
Humulus japonicusExtract improves collagen-induced arthritis in mice by regulating overall joint inflammation
Authors: Kang EJ, et al.

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